Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-235-6
CAS number: 1314-41-6
The lowest NOEC for mammals refers to a full chronic study for mammals
(Morris et al. 1938), which resulted in a NOEC value of 64 mg Pb/kg ww.Sub-chronic
and chronic studies for 3 different mammal species were collected from
literature, ie for Rattus sp. (different strains), Rattus norvegicus and
for mice. For mammal oral toxicity the values varied between 64 and
>12800 mg/kg ww. The lowest value of 64 mg Pb/kg ww was used to derive
the PNEC, which was observed in several experiments with the
Osborn-Mendel rat. According to the guidance, the PNECoral was
calculated from the lowest NOECoral using an assesment factor.
An assessment factor of 6 has been selected on the lowest toxicity data.
Considering a background concentration of 1.3 mg Pb/kg in the food, the
PNECoral can be calculated as:PNECoral= (NOEC +Cb)/AF =
(64+1.3)/6 =10.9 mg/kg food (mammal). This value is further used
for risk characterisation purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again