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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

For the determination of PNECwwtp, the Caspers et al study is the most appropriate. 

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
100 mg/L

Additional information

The Caspers et al study relates to the inhibition of respiration using activated sludge. Therefore the 3 hours EC50 value of >100 mg/l and an NOEC = 100 mg/l may be used to determine a PNECwwtp value of 10 mg/l, using an assessment factor of 10 for 4,4'-MDA according to table R.10 -6 of the Guidance document.