Registration Dossier
Registration Dossier
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EC number: 202-974-4 | CAS number: 101-77-9
Endpoint summary
Administrative data
Description of key information
MDA is acutely and chronic very toxic to aquatic life. Based on data of the most sensitive species daphnia magna.
Additional information
- Acute: Several studies on the acute toxicity of the test item to different fish species are available. The most sensitive and most reliable study (Mitsubishi, 2002) was with test species Oryzias latipes. An LC50 (96h) of 20.6 mg/L was determined. All studies revealed effect values within the same range between 20 and 53 mg/L.
- Acute: After 48 hours of exposure an EC50 of 0.35 mg/L was estimated (BASF, 2011), related to the mean measured concentration. This result indicates that the substance is acutely very toxic to aquatic invertebrates.
- Chronic: The 21d NOEC value of 0.00525 mg/l indicates that MDA is toxic to invertebrates (Mitsubishi, 2002). The results confirm that for 4,4'-MDA invertebrates are the most sensitive species of the three trophic levels (fish, daphnia and algae). Therefore, this NOEC value may be used to derive a PNECaqua
Toxicity to fish
MDA is acutely harmful for fish.
Toxicity to aquatic invertebrates
Toxicity to algae and cyanobacteria
The EC50 (= 14.4 mg/L) and NOEC (= 9.3 mg/L) values based on the growth rate indicate that MDA is acutely harmful to algae.
Toxicity to Microorganism
No inhibition of respiration was determined in activated sludge after 3 h exposure with the test item. An EC50 value of >100 mg/l and an NOEC = 100 mg/l may be used to determine a PNECwwtp value of 10 mg/l, using an assessment factor of 10 for 4,4'-MDA according to table R.10 -6 of the Guidance document.
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