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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

MDA is acutely and chronic very toxic to aquatic life. Based on data of the most sensitive species daphnia magna.

Additional information

Toxicity to fish

MDA is acutely harmful for fish.

  • Acute: Several studies on the acute toxicity of the test item to different fish species are available. The most sensitive and most reliable study (Mitsubishi, 2002) was with test species Oryzias latipes. An LC50 (96h) of 20.6 mg/L was determined. All studies revealed effect values within the same range between 20 and 53 mg/L.

Toxicity to aquatic invertebrates

  • Acute: After 48 hours of exposure an EC50 of 0.35 mg/L was estimated (BASF, 2011), related to the mean measured concentration. This result indicates that the substance is acutely very toxic to aquatic invertebrates.

  • Chronic: The 21d NOEC value of 0.00525 mg/l indicates that MDA is toxic to invertebrates (Mitsubishi, 2002). The results confirm that for 4,4'-MDA invertebrates are the most sensitive species of the three trophic levels (fish, daphnia and algae). Therefore, this NOEC value may be used to derive a PNECaqua

Toxicity to algae and cyanobacteria

The EC50 (= 14.4 mg/L) and NOEC (= 9.3 mg/L) values based on the growth rate indicate that MDA is acutely harmful to algae.

Toxicity to Microorganism

No inhibition of respiration was determined in activated sludge after 3 h exposure with the test item. An EC50 value of >100 mg/l and an NOEC = 100 mg/l may be used to determine a PNECwwtp value of 10 mg/l, using an assessment factor of 10 for 4,4'-MDA according to table R.10 -6 of the Guidance document.