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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09/07/1984-16/07/1984
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented report of a guideline study conducted to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.2400 (Acute Eye Irritation)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-acrylamido-2-methylpropanesulphonic acid
EC Number:
239-268-0
EC Name:
2-acrylamido-2-methylpropanesulphonic acid
Cas Number:
15214-89-8
Molecular formula:
C7H13NO4S
IUPAC Name:
(1Z)-N-(2-methyl-1-sulfopropan-2-yl)prop-2-enimidic acid
Details on test material:
- Name of test material: OS#63466G
- Substance type: organic
- Physical state: solid
- Analytical purity: not specified
- Impurities (identity and concentrations): not specified
- Composition of test material, percentage of components: 100%
- Purity test date: not specified
- Lot/batch No.: not specified
- Expiration date of the lot/batch: not specified
- Stability under test conditions: stable
- Storage condition of test material: not specified

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Ace Animals Inc, Boyertown (PA), USA
- Age at study initiation: not specified
- Weight at study initiation: not specified
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: yes (duration not specified)

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.3-23-9°C (65-75°F)
- Humidity (%): 45-55
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: From: 9/07/1984 To: 16/07/1984

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.1 g
Duration of treatment / exposure:
Single exposure
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6
Details on study design:
REMOVAL OF TEST SUBSTANCE: No

SCORING SYSTEM: Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 hours
Score:
4.7
Max. score:
2
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 hours
Score:
3.3
Max. score:
1
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 72 hours
Score:
3.3
Max. score:
2
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 96 hours
Score:
2.7
Max. score:
1
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 7 days
Score:
2
Max. score:
1

Applicant's summary and conclusion

Interpretation of results:
Category 2A (irritating to eyes)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the test conditions, ATBS was irritating to eyes.