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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate.
Author:
Malorny G
Year:
1969
Bibliographic source:
Zeitschrift Ernährungswissenschaft 9, 332-339.

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium formate
EC Number:
209-677-9
EC Name:
Potassium formate
Cas Number:
590-29-4
Molecular formula:
CH2O2.K
IUPAC Name:
Alcohols, C16-18
Details on test material:
TS-Freetext:
Potassium formate; purity not reported.
Specific details on test material used for the study:
Potassium formate; purity not reported.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
No. of animals per sex per dose:
55

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
95 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
LD50 of formic acid and its salts in the mouse following
i.v. injection:

===========================================================
Substance      LD50      range        LD50           No. of
                                    (formate #)     animals
                 (mg/kg bw)         (mg/kg bw)          n
-----------------------------------------------------------
Formic acid    145      138-151        142             50
Na-formate     807      800-813        534             50
K-formate       95       93-97          51             55
NH4-formate    410      408-412        293             50
Ca-formate     154      150-158        107             55 
===========================================================
# = calculated proportion of formate of the LD50 dose.

Applicant's summary and conclusion

Conclusions:
The LD50 of potassium formate was 95 mg/kg bw in mice following i.v. injection.