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EC number: 253-575-7 | CAS number: 37640-57-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Repeated-dose exposure to melamine cyanurate revealed kidney as the target organ of systemic toxicity at very low doses. The mode of action is precipitation of poorly soluble crystals of the parent compound which is not related to reproductive toxicity.
Experimental data on the components melamine and cyanuric acid show no reproductive toxicity hazard at doses exceeding by far the threshold for melamine cyanurate crystal formation in the kidney. Therefore, both components were tested for fertility or toxicity to reproductive organs at much higher doses that could be tolerated for melamine cyanurate.
Short description of key information:
No adverse effects were observed in a GLP compliant screening study according to OECD testing guideline 422 with cyanuric acid (MHLW 1997). No effects were reported in a short summary of a three-generation study with sodium cynurate applied via drinking water up to the highest dose of 5375 mg/L (Wheeler 1985). No indication of toxicity to reproductive organs were observed in the long-term studies with melamine (US NTP). For melamine cyanurate, a study following the procedure of OECD 421 (feed application) is in the in-life phase (August 2016).
Effects on developmental toxicity
Description of key information
For melamine, no developmental toxicity was observed in a GLP compliant study following OECD testing guideline 414 (BASF 1996). Absence of a teratogenic potential was reported in a short summary of a teratogenicity study with sodium cyanurate (Cascieri 1983) and in a screening study according to OECD 422 (MHLW 1997). A study following the procedure of OECD 421 (feed application) is in the in-life phase (August 2016).the in-life phase (Augu
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The potential for developmental toxicity is derived from experimental data on the components melamine and isocyanuraric acid. Melamine cyanurate is of much more effective in causing nephrotoxicity than either melamine or cyanuric acid by themselves. Therefore, the experimental data on the components is suitable for assessment of a reproductive toxicity hazard. For melamine, no developmental toxicity was observed in a GLP compliant study following OECD testing guideline 414 (BASF 1996); the NOAEL of maternal toxicity was 400 mg/kg bw. Absence of a teratogenic potential at 5000 mg/kg bw was reported in a short summary of a teratogenicity study with sodium cyanurate (Cascieri 1983). No developmental toxicity hazard was identified in a GLP compliant screening study (OECD 422) with cyanuric acid up to the highest tested dose of 600 mg/kg bw (MHLW 1997). The doses tested for the components exceed by far the effective doses causing renal toxicity, therefore it is concluded that melamine cyanurate has no teratogenic properties.
This is confirmed by a supporting developmental toxicity study in rats conducted with a 1:1 mixture of melamine and cyanurate (Kim et al., 2013). In this study, developmental effects were confined to reduced fetal body weight and delayed fetal ossification, which were both noted at a dose level associated with clear maternal toxicity. The 1:1 mixture of melamine and cyanurate was not teratogenic under the conditions of this reliable supporting study.
Toxicity to reproduction: other studies
Additional information
No experimental data is available in how far melamine cyanurate is transferred to human breast milk.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for reproductive toxicity under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for reproductive toxicity under Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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