Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
short-term toxicity to aquatic invertebrates
Data waiving:
other justification
Justification for data waiving:
the study does not need to be conducted because a long-term aquatic toxicity study on invertebrates is available
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
For the detailed read across justification please refer to the attached pdf file.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other:
Remarks:
Frazier
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 2 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other:
Remarks:
Adema
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other:
Remarks:
LeBlanc
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4 438 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other:
Remarks:
Anderson

Description of key information

 In accordance with Regulation (EC) No 1907/2006, Annex VII, Section 9.1.1 Column 1, long-term toxicity testing can be considered instead of short-trerm.

There is a high probability that the product is not acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
200 mg/L

Additional information

For the component CAS 108 -78 -1(melamine):


The study (Frazier 1988) is the newer of both available studies, following the EPA guideline and GLP, and was therefore selected as more reliable. The results of the other study (Adema 1978) were consistent with those of Frazier 1988.


The 24 h and 48 h LC 50 values were both estimated to be > 1000 mg/L. The 24 and 48 hour EC 50 values were 400 and 200 mg/L respectively. The study from Lightner did not reveal effects relevant for the hazard assessment.


 


For the component CAS 108 -80 -5 (cyanuric acid):


Two different species have been tested. 48h LC50 (Daphnia magna) >1000 mg (LeBlanc 1978) and 96h LC50 (Mysidopsis bahia) >4000 mg/L (Anderson 2002).