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Long-term toxicity to fish

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Description of key information

Based on long-term (chronic) toxicity study data, the product is very likely not harmful to fish.

Key value for chemical safety assessment

Additional information

In a key study (BASF SE, 50F0834/09E041, 2016), the fish early life-stage toxicity test of the test substance using fathead minnow (Pimephales promelas) was conducted for a period of 33 days, following the OECD 210 (2013) and the US EPA Guidelines (OPP Subdivision E 72-4 (a) and OPPTS 850.1400. The overall no observed effect concentration (NOEC) was >10 mg/L (nominal concentration). The overall lowest observed effect concentration (LOEC) was >10 mg/L (nominal concentration). 

Furthermore, two valid studies conducted with melamine itself are available (Adema, Goodrich) that did not reveal regulatorily relevant effects.

In addition to the above mentioned studies, several publications are available that used mixtures of melamine and cyanuric acid to expose different fish species via the diet. Similar to mammals crystal formation in the kidneys could be observed. However, the exposure route via the diet is not regarded as relevant as the compounds are not adsorptive. The effects are not regarded relevant for the hazard assessment.