Registration Dossier
Registration Dossier
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EC number: 228-768-4 | CAS number: 6358-31-2
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
The acute toxicity of the test item to fish (zebrafish) was determined according to OECD-Guideline for Testing of Chemicals No. 203 (1992). A static limit test with a saturated solution was conducted. The preparation method has been chosen with regard to the test item properties and in accordance with the relevant OECD guidance document (2000).
Compared to the control, no signs of toxicity could be observed in Danio rerio with the saturated solution. Therefore, the NOEC (96h) was determined to be higher than the concentration of a saturated solution of Pigment Yellow 74 (>= 100 mg/l based on the nominal concentration).
Short-term toxicity to aquatic invertebrates
In an acute immobilisation screening test with Daphnia magna (STRAUS) the effect of the saturated solution (nominally 100 mg/L) of the test item (Pigment Yellow 74) was determined according to OECD 202 (1999, Draft) and Directive 92/69/EC Method C.2 (1992). The limit test was conducted under static conditions over 48 h.
Compared to the control, no signs of toxicity could be observed in Daphnia magna with the saturated solution. Therefore, the NOEC (48h) was determined to be higher than the concentration of a saturated solution of Pigment Yellow 74.
Toxicity to aquatic algae
The toxicity of the test item (Pigment Yellow 74) to the unicellular freshwater green alga Desmodesmus subspicatus was determined according to the principles of OECD-Guideline 201. A limit test with a saturated solution was carried out.
No inhibiting effects on specific growth rate and yield were found in the saturated solution of 2 mg/L. The EC50-values for specific growth rate inhibition (ErC50) and inhibition of yield (EyC50) after 72 h were higher than the saturation level of the test item.
Toxicity to microorganisms
A Respiration Inhibition Test with activated sludge according to OECD Guideline No. 209 was carried out as a limit test. The test was performed under static conditions with the nominal limit concentration of 1000 mg/L. The test item is not toxic at concentrations ≤ 1000 mg/L to activated sludge of a municipal sewage treatment plant.
Long-term toxicity to aquatic invertebrates
A negative control (0 mg/L) and a nominal concentration of 1 mg/L were tested. The tested concentration is already above the limit of solubility of the test substance in water.
Neither immobility nor differences in the onset of brood production was observed in the concentration group in comparison to the control. The reproduction rate in the concentration group showed no statistically significant changes in comparison to the control.
In this prolonged toxicity study in Daphnia magna over 21days the following effect concentrations were obtained:
NOEC (reproduction rate) > 1 mg/L (nominal concentration)
> solubility limit (<=20 µg/L)
NOEC (reproduction rate) > 1 mg/L (nominal concentration)
> solubility limit (<=20 µg/L)
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