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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
The metabolism of cyclo[(14)]hexane and its derivatives
Author:
Elliott TH, Parke DV, Williams RT
Year:
1959
Bibliographic source:
Biochem. J. 72, 193-199

Materials and methods

Objective of study:
absorption
excretion
metabolism
Principles of method if other than guideline:
Urinary excretion of metabolites was evaluated in 2 chinchilla doe rabbits after a single dose of radiolabelled test material.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Test material form:
not specified
Details on test material:
Supplier: British Drug Houses Ltd
Purified, purity not specified.
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source of test material: British Drug House Limited
- Density: 1.465
- Boiling point: 161-162 °C
Radiolabelling:
yes
Remarks:
14C

Test animals

Species:
rabbit
Strain:
Chinchilla
Details on species / strain selection:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
Kept on constant diet (60 g of diet 41, Associated Flour Millers Ltd and 100 mL of water daily)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
single dose application
Doses / concentrations
Remarks:
Doses / Concentrations:260 mg/kg bw
No. of animals per sex per dose / concentration:
2
Control animals:
no

Results and discussion

Preliminary studies:
Cyclohexanol administered orally by gavage to rabbits was readily absorbed. The substance was highly conjugated with glucuronic acid and excreted mainly via the urine (in the two experimental animals, 68 and 75% of the dose was found as radioactivity in the urine). The main metabolites were cyclohexyl glucuronide (about 60% of administered dose) and trans-cyclohexane-1:2-diol glucoronide (about 6% of administered dose). Negligible amounts of cyclohexanol were found in the expired air.

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Toxicokinetic parameters:
other: no data

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Cyclohexyl glucuronide (about 60%), trans-cyclohexane-1:2-diol glucuronide (about 6%)

Applicant's summary and conclusion

Conclusions:
Cyclohexanol administered orally by gavage to rabbits was readily absorbed. The substance was highly conjugated with glucuronic acid and excreted mainly via the urine (in the two experimental animals, 68 and 75% of the dose was found as radioactivity in the urine). The main metabolites were cyclohexyl glucuronide (about 60% of administered dose) and trans-cyclohexane-1:2-diol glucoronide (about 6% of administered dose). Negligible amounts of cyclohexanol were found in the expired air.