Cyclohexanol

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

bulk density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Good detail on experimental apparatus and calibration, however, no detail on number of repeat measurements.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Principles of method if other than guideline:

Apparatus described Picker, P., et al, J. Solution Chem., 1974, 3, 377

GLP compliance:

no

Type of method:

oscillating densitimeter

Remarks:

tube densimeter

Type:

bulk density

Density:

0.945 g/cm³

Temp.:

25 °C

Reference 2

Endpoint:

bulk density

Remarks:

density

Type of information:

other: statistical review

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Statistical approach to available data, however, no attempt was made weight individual reported densities for quality.

Qualifier:

no guideline followed

Principles of method if other than guideline:

The mean density was calculated for multiple measurements reported in the literature.

GLP compliance:

no

Type of method:

other: statistical review

Type:

bulk density

Density:

0.945 g/cm³

Temp.:

25 °C

Remarks on result:

other: 95%C.I. 0.94498 – 0.94574g/cm3

Conclusions:

The mean literature density for cyclohexanol is 0.94536 g/cm3 (0.94498 – 0.94574g/cm3) at 25°C.In addition to experimental uncertainty in the density measurement, the above statistical value can be expected to encompass variation due to sample purity. Bias introduced by data recycling cannot be excluded, but has been attempted to be controlled for, although without inspection of every reference.

Description of key information

0.94536 g/cm3 (0.94498 – 0.94574 g/cm3) at 25 °C, mean literature value, n=9
0.94496 g/cm3, 25 °C, oscillating tube densimeter, Hovorka 1999

Key value for chemical safety assessment

Relative density at 20C:

0.945

Additional information

A survey of available literature data was carried out for the density of cyclohexanol in the liquid state (25 °C), rather than at the standard 20 °C. The potential data sources were restricted to two bibliographic databases, augmented by data from other studies previously identified. No attempt was made to weight individual studies by reliability, instead a statistical approach was taken. Data from obvious secondary sources, and multiple reports of a numerically equivalent density by the same authors, were discarded as potential sources of bias due to data recycling. Data points lying outside two standard deviations, most likely resulting from impurities, unreported or misreported experimental conditions, or bibliographic indexing mistakes, were treated as outliers and discarded.

One reference was explored in further detail, and found to be of sufficient quality for use as a standalone study (Hovorka 1999).

The mean value is taken forward for the purposes of risk assessment, as being most representative of the commercial substance. The available data is considered to be relevant, reliable, and adequate for risk assessment purposes. The endpoint is complete, in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.1.1.