Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Acute Toxicity-Oral LD50=6318 mg/kg in rats (OECD TG 401)
Acute Toxicity-Dermal LD50>2000 mg/kg in rabbits (OECD TG 402)
Acute Toxicity-Inhalation LC50> 4688 mg/m3 (OECD TG 403)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
6 318 mg/kg bw

Additional information

The acute toxicity of C10-C12 Aromatics has been fully evaluated.  All of the animal studies were performed in a manner similar or equivalent to currently established OECD guidelines.  Based on these data, C10-C12 Aromatics have a low order of acute toxicity by the oral, dermal, and inhalation routes of exposure.

Justification for classification or non-classification

The test substance, C10-C12 Aromatics, is minimally toxic via ingestion where the LD50 is 6318 mg/kg, via dermal exposure where the LD50 is >2000mg/kg, and by inhalation where the LC50 > 4688 mg/m3.  These findings do not warrant classification of C10-C12 Aromatics under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) and do not warrant classification under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations (DSD/DPD). The test substance, C10-C12 Aromatics, is classified under EU CLP guidelines as a Category 1 aspiration hazard based on its physical and chemical properties (hydrocarbon fluid, viscosity ≤ 20,5 mm2/s) and as an R65 aspiration hazard under the EU DSD/DPD.