Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 919-284-0 | CAS number: -
Dermal absorption
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Source of data is from peer reviewed literature. Acceptable well-documented study report which meets basic scientific principles: non-GLP.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- dermal absorption
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Source of data is from peer reviewed literature. Acceptable well-documented study report which meets basic scientific principles: non-GLP.
- Reason / purpose for cross-reference:
- read-across source
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
- Conclusions:
- The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
- Executive summary:
This data is being read across from the source study that tested naphthalene, 1-methyl naphthalene and 2-methylnaphthalene based on analogue read across.
A mathematical model was developed to describe the diffusion coefficients (Dsc) of aromatic hydrocarbons. The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mathematical description of the uptake of hydrocarbons in jet fuel into the stratum corneum of human volunteers.
- Author:
- Kim, David; Matthew W. Farthing; Cass T. Miller; Nylander-French, Leena A.
- Year:
- 2 008
- Bibliographic source:
- Toxicology Letters 178 (2008) 146-151
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A mathematical description/model was developed to describe the uptake of aromatic hydrocarbons into the stratum corneum of human skin in vivo. The dermal absorption data was gathered in a previous paper (Kim 2006).
Kim, D., Andersen, ME., Nylander-French, L.A., 2006a. Dermal absorption and penetration of jet fuel components in humans. Toxicol. Lett. 165, 11-21. - GLP compliance:
- no
Test material
- Reference substance name:
- Naphthalene
- EC Number:
- 202-049-5
- EC Name:
- Naphthalene
- Cas Number:
- 91-20-3
- Molecular formula:
- C10H8
- IUPAC Name:
- naphthalene
- Reference substance name:
- 1-methylnaphthalene
- EC Number:
- 201-966-8
- EC Name:
- 1-methylnaphthalene
- Cas Number:
- 90-12-0
- Molecular formula:
- C11H10
- IUPAC Name:
- 1-methylnaphthalene
- Reference substance name:
- 2-methylnaphthalene
- EC Number:
- 202-078-3
- EC Name:
- 2-methylnaphthalene
- Cas Number:
- 91-57-6
- Molecular formula:
- C11H10
- IUPAC Name:
- 2-methylnaphthalene
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- no
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
Applicant's summary and conclusion
- Conclusions:
- The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
- Executive summary:
A mathematical model was developed to describe the diffusion coefficients (Dsc) of aromatic hydrocarbons. The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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