Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-615-1 | CAS number: 97-88-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryonic-fetal toxicity and teratogenic effects of a group of ethacrylate esters in rats.
- Author:
- Singh AR, Lawrence WH, Autian J
- Year:
- 1 972
- Bibliographic source:
- J. Dental. Res. 519(6): 1632-1638
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 688-84-6
- Details on test material:
- n-Butyl methacrylate, purity not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The test animals were 175 to 225 gm, adult, virgin female rats. Male rats of the same strain and age were used as the "stud pool".
Administration / exposure
- Route of administration:
- intraperitoneal
- Details on study design:
- Acute toxicity was determined by administration of graded doses of these specific samples by intraperitoneal injection in rats and observation of the rats for 7 days for mortality.
- Statistics:
- Acute LD50-values and 95 % confidence limits were calculated by Cornfield and Mantel's modification of Karber's method or by the method of Weil.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 059 mg/kg bw
Any other information on results incl. tables
Original value: 2.3039 ml/kg (1.8811 - 2.8217 ml/kg 95 % confidence limit)
Density: 0.8948 g/cm3
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
