Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
other:
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Principles of method if other than guideline:
A drop of bromine was directly applied to the eye, and was washed out after 5 seconds.

Test material

Constituent 1
Chemical structure
Reference substance name:
Bromine
EC Number:
231-778-1
EC Name:
Bromine
Cas Number:
7726-95-6
Molecular formula:
Br2
IUPAC Name:
dibromine

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Amount / concentration applied:
Drop applied
Duration of treatment / exposure:
5 seconds
Observation period (in vivo):
1 minute and thereafter

Results and discussion

In vivo

Results
Irritation parameter:
other:
Time point:
other: less than one minute
Remarks on result:
other: Cornea opaque where drop hit
Irritant / corrosive response data:
Even with washout in 5 seconds, animals showed severe initial pain with marked tissue necrosis in less than one minute. Cornea was observed to be opaque where drop hit. Probable permanent corneal damage and impairment of vision. Bromine and bromine chloride data were the same.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Bromine liquid is corrosive to eye tissues, even with 5 second washout. Damage is likely to be permanent.
Executive summary:

Bromine liquid was corrosive to rabbit eyes when applied neat with 5 second washout.