Registration Dossier
Registration Dossier
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EC number: 203-051-9 | CAS number: 102-76-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature. Original report not available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of triacetin.
- Author:
- Fiume, M.Z.
- Year:
- 2 003
- Bibliographic source:
- Int J Toxicol. 2003;22 Suppl 2:1-10.
- Reference Type:
- other: letter
- Title:
- Letter dated September 13 from Dr. Anstadt, Eastman Kodak Co., to D. R. Mathieu, Flavor and Extract Manufacturer’s Association, regarding information on the toxicity of Triacetin.
- Author:
- Anstadt, G.W.
- Year:
- 1 976
- Bibliographic source:
- Data submitted by FDA in response to an FOI request.
- Reference Type:
- other: summary information
- Title:
- Summary information on Triacetin. Unpublished data received from CTFA. 32 pages.
- Author:
- Unichema Chemie B.V.
- Year:
- 1 994
- Bibliographic source:
- Available for review. Director, Cosmetic Ingredient Review, 1101 17th Street, N.W., Suite 310, Washington, DC 20036, USA.
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
- Principles of method if other than guideline:
- Different methods were used to test the skin sensitization potential in guinea pigs.
- GLP compliance:
- no
- Type of study:
- other: drop-on method
Test material
- Reference substance name:
- Triacetin
- EC Number:
- 203-051-9
- EC Name:
- Triacetin
- Cas Number:
- 102-76-1
- Molecular formula:
- C9H14O6
- IUPAC Name:
- 1,3-bis(acetyloxy)propan-2-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): triacetin
- Analytical purity: no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: not specified
- Sex:
- not specified
Results and discussion
Any other information on results incl. tables
Several animal studies and studies in human subjects were summarised.
The available informations were jugded to be sufficient to classify glycerol triacetate as not skin sensitising.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
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