Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: review article
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Triacetin CAS No. 102-76-1
Author:
OECD SIDS
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report For SIAM 15
Report Date:
2002
Reference Type:
publication
Title:
Evaluation of certain food additives some food colours, thickening agents, and certain other substances
Author:
JECFA
Year:
1975
Bibliographic source:
WHO Fd Add. Ser. 8. FAO Nutr. Mtg Rep. Ser. No. 55. 19th Report of the Joint FAO/WHO Expert Committee on Food Additives.
Reference Type:
publication
Title:
Reports of the Scientific Committee for Food (26th series)
Author:
Commission
Year:
1992
Bibliographic source:
EUR 13913 EN. Luxembourg.
Reference Type:
publication
Title:
Steering Group on Chemical Aspects of Food Surveillance. Food
Author:
MAFF
Year:
1993

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
Anticipated daily intake: 7.8 mg/day/adult
There is no information on human toxicity available. However, the Joint FAO/WHO Expert Committee on Food Additive (JECFA) considers it unnecessary to assign an acceptable daily intake (ADI) as triacetin is metabolized like other triglycerides in food. In an assessment of triacetin, JECFA concluded that based on the available data, and anticipated daily intake, triacetin did not represent a hazard to health (JECFA, 1975) and in a more recent evaluation, the EU’s Scientific Committee for Food endorsed this position for triacetin (Commission, 1992, SCF, 1995). An estimate of additive intake in the UK suggests that an adult might ingest 7.8 mg triacetin/day as part of a total daily additive intake of 8.0 g (MAFF, 1993).

Applicant's summary and conclusion