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Diss Factsheets
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EC number: 203-180-0 | CAS number: 104-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Read across from a member of the Hydrotropes category
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- 20 adults (10 male, 10 female); single exposure for 24 hours; two dosage levels; full suite of observations and measures for 14 days.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium (xylenes and 4-ethylbenzene) sulfonates
- EC Number:
- 701-037-1
- Molecular formula:
- -
- IUPAC Name:
- Sodium (xylenes and 4-ethylbenzene) sulfonates
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: no data- Age at study initiation: "young"- Weight at study initiation: 2.49 to 3.01 kg- Fasting period before study: no data- Housing: individually housed in metal cages elevated above the droppings- Diet (e.g. ad libitum): ad libitum- Water (e.g. ad libitum): ad libitum- Acclimation period: 14 days minimumENVIRONMENTAL CONDITIONS- Temperature (°C): no data- Humidity (%): no data- Air changes (per hr): no data - Photoperiod (hrs dark / hrs light): no dataIN-LIFE DATES: From: July 18 To: August 1, 1979
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE- Area of exposure: trunk; clipped free of hair and epidermal abraded very two or three centimeters longitudinally over the area of exposure. The abrasions were sufficiently deep to penetrate the stratum corneum but not deep enough to disturb the derma.- % coverage: no data- Type of wrap if used: plastic binder secured with adhesive tapeREMOVAL OF TEST SUBSTANCE- Washing (if done): excess wiped with a paper towel- Time after start of exposure: 24 hoursTEST MATERIAL- Amount(s) applied (volume or weight with unit): no data- Concentration (if solution): undiluted- Constant volume or concentration used: yesVEHICLE- Amount(s) applied (volume or weight with unit): no vehicle
- Duration of exposure:
- 24 hours
- Doses:
- 0.5 and 2.0 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: observations daily for 5 days/wk; weighing at 7 and 14 days after dosing - Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight,organ weights, histopathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: At 72-hour reading, 6 of 20 showed minimal erythema and/or edema of the skin at the treatment site. During the second week of the observation period, 10 of 20 showed minimal to slight fissuring, dryness and/or desquamation of the skin.A wry neck condition
- Gross pathology:
- 19 of the 20 animals showed tissues to be not remarkable. A decrease of visceral fatty tissue and an accumulation of clear watery fluid within the peritoneal cavity were noted in the remaining animal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 is > 2000 mg/kg bw based on test material.
- Executive summary:
The acute dermal toxicity of Sodium (xylenes and 4-ethylbenzene) sulfonates was assessed following official method OECD 402, Acute dermal Toxicity. At 72-hour reading, 6 of 20 showed minimal erythema and/or edema of the skin at the treatment site. During the second week of the observation period, 10 of 20 showed minimal to slight fissuring, dryness and/or desquamation of the skin. 19 of the 20 animals showed tissues to be not remarkable. A decrease of visceral fatty tissue and an accumulation of clear watery fluid within the peritoneal cavity were noted in the remaining animal.
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