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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a guideline study but with considerable documentation

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
HF Smythe, CP Carpender, CS Weil, UC Pozzani, JA Striegel
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal 23:95-107

Materials and methods

Principles of method if other than guideline:
Males only; 5 animals per dose, a logarithmic series of single doses; mortality recorded through 14 days
GLP compliance:
no
Test type:
other: not reported
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): benzenesulfonic acid
- Substance type: organic

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: in house colony
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: not reported
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported

ENVIRONMENTAL CONDITIONS - not reported

IN-LIFE DATES: From: To: - not reported

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses:
not reported other than a logarithmic series differing by a factor of two
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: not reported
Statistics:
method of Thompson using Tables of Weil

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 1 104 mg/kg bw
Based on:
not specified
Mortality:
not reported
Clinical signs:
not reported
Body weight:
not reported
Gross pathology:
not reported

Any other information on results incl. tables

The LD50 is >0.89 (0.36 - 3.21) ml/kg bw which is equivalent to 1104 mg/kg bw (d = 1.24 g/cm3)

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test substance has a relatively low acute oral toxicity