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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003-05-13 to 2003-07-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Well documented, scientifically sound study that was conducted in accordance to GLP and OECD Guideline 423; limit test.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tungsten oxide
EC Number:
254-413-8
EC Name:
Tungsten oxide
Cas Number:
39318-18-8
Molecular formula:
WOn (n=2.99 to 2.90)
IUPAC Name:
Tungsten oxide
Details on test material:
- Name of test material (as cited in study report): Tungsten oxide blue
- Molecular formula (if other than submission substance): WO
- Physical state: Blue to black powder
- Analytical purity: 99.9%
- Purity test date: 2003-04-15
- Stability under test conditions: 5 years
- Storage condition of test material: Ambient temperature
- Other: Solubility in water- 118 mg/L at 20 degrees C
- pH: 6.9

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: No severe toxic effects were present after a single dose of 2000 mg/kg of the test substance.

Applicant's summary and conclusion

Conclusions:
No severe toxic effects of tungsten oxide were noted by signs in life and post mortem. No mortality occurred. An LD50 of > 2000 mg/kg body weight for rats was established for the test substance.