Trichloro(methyl)silane

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1981

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. It was not compliant with GLP and the applied dose was smaller than current guideline requirements.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

not specified

Remarks:

Although a GLP statement was not included with the report, it is known that Bushy Run Research Center (BRRC) operated as a GLP-facility at the time the testing was conducted.

Test material

Test material information

Constituent 1

Reference substance name:

Trichloro(methyl)silane

EC Number:

200-902-6

EC Name:

Trichloro(methyl)silane

Cas Number:

75-79-6

Molecular formula:

CH3Cl3Si

IUPAC Name:

trichloro(methyl)silane

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

The sex of the rabbits used in this study was not specified.

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

undiluted
Amount applied: 0.005 ml

Duration of treatment / exposure:

Eyes were held closed for one second after application. The eyes were not rinsed.

Observation period (in vivo):

21 days

Number of animals or in vitro replicates:

6

Details on study design:

The dose was instilled into the lower conjunctival sac of one eye per animal. The eyelids were held together for one second. The eyes were scored by the Draize scale at one hour, approximately 6 hours, and at 1, 2, 3, 7, 14, 21 or 36 days after dosing. Fluorescein (2%) staining was used to determine corneal injury before dosing at readings after one day.

Comment: not rinsed

Results and discussion

Any other information on results incl. tables

Instillation of the smallest volume included in the standard eye test, 0.005 ml, resulted in moderate to severe reddening and swelling of the conjunctivae with mild to severe corneal injury.  The corneal opacities prevented an accurate assessment of the condition of the iris.  Effects on the conjunctivae and cornea appeared within an hour of the application and persisted in many cases for 14 days.  One dosed rabbit died at 13 days.  The cause of death was uncertain.  Injury to the remaining rabbit eyes persisted for more than 21 days, although it had become less severe.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Administration of the undiluted material resulted in severe eye injury.