Registration Dossier
Registration Dossier
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EC number: 297-907-9 | CAS number: 93763-87-2 Substance formed by processing of chiefly oxidic material with lead and zinc content in a rotating furnace. Consists primarily of Al2O3, CaO, Fe, FeO and SiO2 with other nonferrous compounds as well as carbon.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented and scientifically good . Not according to GLP nor to specific test guidelines.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Principles of method if other than guideline:
- A study was conducted to evaluate the acute dermal toxicity of the test material in rats. The rats were exposed to a dose of 2.000mg/kg bw of the tes material and observed during a period of 14 days
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Slags, lead-zinc smelting
- EC Number:
- 297-907-9
- EC Name:
- Slags, lead-zinc smelting
- Cas Number:
- 93763-87-2
- Molecular formula:
- not applicable
- IUPAC Name:
- Slags, lead-zinc smelting
- Details on test material:
- name of test substance: Ferrosita (Spanish brand name for Waelz-slag)
origin of test substance: Befasa Zinc Aser S.A.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: firma Harlan
- Weight at study initiation: ± 190g
- Housing: individual cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 14 days observation period
- Doses:
- 2000mg/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no statistics reported
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no deaths
- Clinical signs:
- no data
- Body weight:
- slight increases
- Gross pathology:
- no data
- Other findings:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The sample Ferrosita is not harmful neither toxic via the dermal route
- Executive summary:
This study report demonstrated no acute dermal toxicity for the sample 'Ferrosita'
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