Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
1961
Report Date:
1961
Reference Type:
secondary source
Title:
No information
Author:
BASF AG
Bibliographic source:
ECB IUCLID dataset
Reference Type:
secondary source
Title:
No information
Author:
BASF AG
Year:
2000
Bibliographic source:
OECD SIDS
Reference Type:
secondary source
Title:
1,6-Hexanediol
Author:
GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Year:
1992
Bibliographic source:
BUA Report 107 (October 1992)

Materials and methods

Principles of method if other than guideline:
Internal BASF method was used
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
other: "Hannover"
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
TEST MATERIAL
-Concentration: 10%, 20%
Doses:
800, 1600, 2000, 2500, 3200, 4600 mg/kg bw
No. of animals per sex per dose:
5 animals/dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 2 300 mg/kg bw
Mortality:
800 mg/kg bw: 1/5 within 7 days (killed by cohoused animals)
1600 mg/kg bw: 0/5
2000 mg/kg bw: 0/5
2500 mg/kg bw. 3/5 within 24 h; 4/5 within 7 days
3200 mg/kg bw: 5/5 within 24 h
6400 mg/kg bw: 5/5 within 24 h
Clinical signs:
800 mg/kg bw: staggering and slight hyperactivity
1600 mg/kg bw: hyperactivity; lateral position, accelerated respiration, atonia, after 4 h without symptomps
2000 mg/kg bw: staggering, atonia, lateral position, intermittent respiration, narcotic state, after 3 days without symptoms
2500 mg/kg bw: hyperactivity, lateral positionor or back posture, atonia, intermittent respiration, 2 deaths within 4 h
3200 mg/kg bw: hyperactivity, lateral positionor or back posture, atonia, intermittent respiration,3 deaths within 5 h, white-colored eyes after exitus
6400 mg/kg bw: intermittent respiration, lateral position or back posture, atonia, narcotic state, deaths within 1 - 4 h; white-colored eyes after exitus
Gross pathology:
no abnormalities found

Applicant's summary and conclusion