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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Internal BASF method was used, which was in large part equivalent to methods described in OECD guideline 402
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexane-1,6-diol
EC Number:
211-074-0
EC Name:
Hexane-1,6-diol
Cas Number:
629-11-8
Molecular formula:
C6H14O2
IUPAC Name:
hexane-1,6-diol
Details on test material:
- Name of test material (as cited in study report): Hexandiol-1,6
- Test substance No.: 81/161

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: M. GAUKLER, 6050 Offenbach, Germany
- Weight at study initiation: mean 2.9 kg (male), 3.2 kg (female)
- Diet (e.g. ad libitum): Ovator Solikanin 4 mm, Muskator-Werke, 4000 Düsseldorf, Germany; ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Type of coverage:
occlusive
Vehicle:
CMC (carboxymethyl cellulose)
Details on dermal exposure:
TEST SITE
- Area of exposure: clipped dorsal and lateral part of back and flanks
- Type of wrap if used: inert foil covered with adhesive tape


REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water and/or water/lutrol mixture
- Time after start of exposure: 24 h


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2500 mg/kg bw
- Concentration (if solution): 50%
- Constant volume or concentration used: yes
- For solids, paste formed: yes


VEHICLE
- Concentration (if solution): 0.5% CMC in water
Duration of exposure:
24 h
Doses:
2500 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: daily observations, weighing prior to study begin
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, skin irritation, mortality

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Mortality:
no mortalities
Clinical signs:
other: - within 20 min: slight apathy in 1/5 female - within 30 min: slight apathy in 1/5 male - slight skin irritation in 1/5 males, which disappears after 5 days - slight skin irritation in1/5 female after 24 h, which disappear within 48 h
Gross pathology:
no abnormalities found

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU