Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Studies in Detoxication - The Metabolism of Glycols
Author:
Gessner PK, Parke DV and Williams RT
Year:
1960
Bibliographic source:
Biochem. J. 74: 1-5
Reference Type:
secondary source
Title:
No information
Author:
Gessner PK, Parke DV and Williams RT
Year:
2000
Bibliographic source:
ECB IUCLID dataset
Reference Type:
secondary source
Title:
HEXAMETHYLENE GLYCOL CAS NO. 629-11-8
Author:
Gessner PK, Parke DV and Williams RT
Year:
2000
Bibliographic source:
OECD SIDS
Reference Type:
secondary source
Title:
Unnamed
Year:
1982

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
Chinchilla
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2 - 3 kg
- Diet (e.g. ad libitum): 60 g of rat cubes (diet 41 ; Associated London Flour Milers) per day
- Water (e.g. ad libitum): 100 ml water, per day

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
0.75 g/kg bw; 2 mmol/kg bw
No. of animals per sex per dose:
4 animals
Control animals:
no

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
metabolite glucuronide, adipic acid

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
glucuronide, adipic acid

Applicant's summary and conclusion