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In a non guideline study 80 mg 1,6 Hexandiol was applied directly to the open nerve of one ore more Sprague Dawley rats. After local application to the nervous tissue 1,6-hexanediol causes no and 2,5-hexanedione causes changes of the neurofilaments and swelling of Schwann's cells. This correlates with the systemic neurotoxic effect of both substances.

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