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Diss Factsheets
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EC number: 209-008-0 | CAS number: 552-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No studies are available. The available data from genetic toxicity and sub-chronic toxicity studies do not suggest a concern for carcinogenicity and it is proposed that testing shall be waived on the basis that sufficient information is available on the end-point by reference to structurally related substances.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No classification is proposed. There is no evidence from genetic toxicity or sub-chronic toxicity studies that the substance is likely to be carcinogenic.
Additional information
No data are available on the chronic toxicity or carcinogenicity of trimellitic anhydride (TMA). Adequate testing for genetic toxicity in vitro has revealed no evidence of genotoxicity, suggesting that the substance is not a genotoxic carcinogen. Numerous sub-chronic toxicity studies are available for the substance and do not indicate any pre-neoplastic effects. The endpoint of concern for this substance is clearly identified as respiratory sensitisation. Read-across studies for the hydrolysis product trimellitic acid similarly do not indicate any concerns and demonstrate very low sub-chronic toxicity.
TMA is a cyclic anhydride and many cyclic anhydrides have a similar structure, containing a bicyclic ring structure with the carboxylic acid anhydride group being the reactive and toxicologically functional moiety. The bicyclic ring structure may be saturated or partially unsaturated and may contain substituted methyl derivatives. Substances with substituted methyl groups may exist as several isomeric forms.
While little information on the carcinogenicity of cyclic anhydrides is available, long-term feeding studies of phthalic anhydride in rodents has revealed no evidence of carcinogenicity [Kluwe WM, McConnell EE, Huff JE, Haseman JK, Douglas JF, Hartwell WV (1982); Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute. Environmental Health Perspectives, 45: 129–133; Shelby MD, Stasiewicz S (1984) Chemicals showing no evidence of carcinogenicity in long-term, two-species rodent studies: The need for short-term test data. Environmental Mutagenesis, 6: 871–878;
Kluwe WM (1986) Carcinogenic potential of phthalic acid esters and related compounds: Structure activity relationships. Environmental Health Perspectives, 65: 271–278; Haseman JK, Huff JE, Zeiger E, McConnell EE (1987) Comparative results of 327 chemical carcinogenicity studies. Environmental Health Perspectives, 74: 229–235].
The available data do not suggest a concern and it is proposed that testing shall be waived on the basis that sufficient information is available on the end-point.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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