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EC number: 266-936-9 | CAS number: 67701-12-6 This substance is identified by SDA Substance Name: C14-C18 and C16-C18 unsaturated alkyl carboxylic acid zinc salt and SDA Reporting Number: 04-006-09.
Table 1. Changes in plasma zinc levels following the oral zinc oxide administration
Plasma Zinc (µg/dL) (mean±SD)
113.0 ± 22.0
105.3 ± 18.8
After Zn administration
112.9 ± 20.7
1 h 30 min
143.4 ± 43.6
2 h 30 min
159.3 ± 29.5
3 h 30 min
126.3 ± 25.9
4 h 30 min
113.9 ± 29.8
5 h 30 min
98.4 ± 23.1
Oral zinc tolerance test was performed in humans to study the absorption of zinc from various zinc compounds including zinc oxide.
Six female and four male volunteers were administered orally a zinc compound capsule containing 50 mg elemental zinc. Two blood samples were drawn (15 min. apart) for baseline data at initiation of study. Further samples were drawn at 30 min. and thereafter at hourly intervals for 5 h after drug administration. Various zinc compounds (zinc acetate, zinc oxide, zinc sulfate, zinc aminoate and zinc methionine) were tested as described at same dose level in same individuals after every 2 wk intervals.
Zinc was least absorbed after oral administration of zinc oxide among all the zinc compounds tested. Peak plasma concentration of 159.3 ± 29.5 µg/dL reached after 2.5 h of zinc oxide administration. Plasma concentration reached the near baseline value after 4.5 h. Area under the curve generated by percent changes in plasma zinc was lowest (~ 500) after zinc oxide administration among all the zinc compounds tested. A comparison of AUC values for different zinc forms were compared, it appeared that the bioavailability of zinc oxide was about 60% of the bioavailability of the soluble forms.
Under the study conditions, zinc oxide was least absorbed among all the zinc compounds tested.
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