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Toxicological information

Carcinogenicity

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Description of key information

Rats were dosed five days per week for one year by gavage at a dose level of 300 mg/kg body weight.  HFC-143a was dissolved in corn oil.  They were held for an additional year  and sacrificed.  No treatment related tumors were found.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
NOAEL
300 mg/kg bw/day

Additional information

Test article (HFC-143a) did not cause a carcinogenic response in this screening study. (Ref. Longstaff, E., Robinson, M., Bradbrook, C., Styles, JA., and Purchase, IFH., (1984). Genotoxicity and Carcinogenicity of fluorocarbons: Assessment by short-term in vitro tests and chronic exposures in rats. Toxicol. Appl. Pharmacol. 72, 15 -31.

Carcinogenicity: via oral route (target organ): other: all gross lesions and masses

Justification for classification or non-classification

HFC-143a did not show a carcinogenic response.