Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

1,1,1-trifluoroethane is a gas at room temperature.  In 4-hour  inhalation exposures, there was no mortality or significant signs of toxicity even with exposures up to 2030000 mg/l (591000 ppm).  

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Endpoint conclusion
2 030 000 mg/m³ air

Additional information

Rats were exposed for 4 -hours to levels upto 2030000mg/m3. There was no mortality and they were no significant signs of toxicity. The potential of 1,1,1 -trifluoroethane to sensitize the heart to adrenalin was evaluated in the dog. The no effect level was 860000 mg/m3 (250000 ppm) and the threshold for an effect (cardiac arrhythmia) was 1040000 mg/m3 (300000 ppm).

Justification for classification or non-classification

The data do not meet the requirements for classification and labeling.