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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Propane-1,2-diol, propoxylated
- EC Number:
- 500-039-8
- EC Name:
- Propane-1,2-diol, propoxylated
- Cas Number:
- 25322-69-4
- Molecular formula:
- (C3 H6 O)n H2 O n= >1 - <4.5
- IUPAC Name:
- propane-1,2-diol, propoxylated
- Details on test material:
- Name: Propane-1,2-diol propoxylated
Molecular weight: Mn = 260 g/mole
Physical state: clear, colourless, slightly viscous liquid
Composition of test material, percentage of components: Propylene oxide - 100%
Lot number: T103APR02
Storage condition of test material: room temperature in the dark
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS: Mouse
- Strain: CBA/Ca
- Sex: female
- Source: B&K Universal Ltd, Hull, UK
- Age: 7-12 weeks
- Weight at study initiation: 15-23 g
- Number of animals: 20
- Controls: Solvent and positive controls
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0.5, 5 and 50%
- No. of animals per dose:
- 5
- Details on study design:
- ADMINISTRATION/EXPOSURE
- Study type: Local lymph node assay
- Preparation of test substance for induction: In acetone/olive oil 4:1
- Induction schedule: Daily application of 25 ul of the test solution to the dorsal surface of each ear for 3 consecutive days.
- Assessment procedure: After 2 days without treatment the mice were injected in the tail vein with 3H-methyl thymidine and after 5 hours the draining auricular lymph nodes were excised and processed for each individual animal.
- Concentrations used for induction: 0.5, 5 and 50%
- Positive control: A summary of positive control data (non-current) which indicated that the assay used produced a positive response was provided. The positive controls included hexyl cinnamic aldehyde.
EXAMINATIONS
- Assessment system: The incorporation of 3H-methyl thymidine was measured by beta-scintillation counting as disintegrations per minute (DPM) using a Beckman LS6500 scintillation system and reported as a stimulation index (the ratio of 3HTdR incorporation into lymph node celss relative to controls).
- Evaluation criteria: The test is considered positive if at least one concentration results in >= threefold increase in 3HTdR incorporation compared to controls
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: A stimulation index (SI) of less than 3 was recorded for all test concentrations. 0.5%: SI 1.00, 5% : SI 0.60 and 50% : SI 1.40.
Any other information on results incl. tables
Clinical signs: There were no deaths or clinical signs of intoxication. Body weights were comparable between test and control groups.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Propane-1,2-diol propoxylated (molecular weight 230) was considered to be a non-sensitiser under the conditions of this local lymph node assay.
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