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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
An LLNA study was conducted with MPG, propoxylated, according to OECD 429. Female CBA/Ca mice (twenty/group) received 0.5%, 5%, or 50% (v/v) test substance diluted using 4:1 acetone:olive oil (AOO). Lymph node stimulation indices of less than three (3) were measured for all the test groups relative to AOO vehicle mice. The test substance was considered to be a non-sensitizer under the conditions of the test.
Tetrapropylene Glycol, a major component of PPG, has been tested for dermal sensitization (Buehler teste with induction and challenge phases) in male Guinea pigs (Dow, 1996). Although the tests were not conducted according to a guideline or GLPs, adequate information was available to determine the tests and resulting data are reliable. A range-finding test was conducted in 4 Guinea pigs to determine the highest non-irritating concentration of test material. Following 6-h administration of 0.4 ml of test material (as 100, 75, 50, 25, or 10% aqueous solution), the skin was evaluated for signs of irritation. Neither erythema nor edema were observed at up to 100% test material. Therefore the additional tests were conducted with neat material. The definitive dermal sensitization test, with 10 Guinea pigs per treatment, had two phases: induction and challenge phases, and included positive (DCNB and DER-331) and negative controls (distilled water). The left side clipped skin sites of 10 male Guinea pigs were fitted with Hilltop Chambers and treated with test material, DCNB, DER-331, or water for 6 h. The following day, the treated sites were evaluated for erythema and edema. For 3 consecutive weeks, this treatment was repeated at weekly intervals (induction phase). Following a 2-week interval after the final induction treatment, the right side sites, clipped free of hair, were treated with test material, DCNB, DER-331, or water (challenge phase). In addition, naïve animals were clipped and treated similarly: 4 with Tetrapropylene Glycol, 5 with DCNB, and 5 with DER-331 to serve as challenge controls. At 24-h and 48-h post-challenge treatment, all the challenge sites were depilated and evaluated for sensitization response and the challenge control sites for irritation. No mortalities occurred and all animals appeared in good health; there was no evidence of irritation at the treated sites. For DCNB, by 48-h post-challenge, 10 out of 10 animals were graded aspositive for sensitization response, while none of the DCNB-treated challenge controls were positive for irritation. For DER-331, by 48-h post-challenge, 8 out of 10 animals were graded as positive for sensitization response, while none of the DER-331-treated challenge controls were positive for irritation. Tetrapropylene Glycol-treated animals did not demonstrate a positive response at 24 h or 48 h post-challenge, neither the induction/challenge animals nor the challenge control animals.
Based on the results, Tetrapropylene Glycol is considered as non-sensitizing.
Migrated from Short description of key information:
MPG, propoxylated is a non-sensitizer using the mouse LLNA (OECD 429)
Based on the skin irritation results for both Tetrapropylene Glycol and Tetrapropylene Glycol Crude (Tripropylene Glycol Bottoms) classification is not warranted in accordance with Directive 67/548/EEC and EU Classification, Labelling, and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. Based on eye irritation results for Tetrapropylene Glycol and Tetrapropylene Glycol Crude (Tripropylene Glycol Bottoms), instillation of neat test material was slightly (or moderately) irritating, however all clinical signs were completely resolved by 7 days post-instillation. Given the complete resolution by 72 h or 7 days, and the minimal eye effects noted, the classification of Tetrapropylene Glycol Crude (Tripropylene Glycol Bottoms) for eye irritation is not warranted in accordance to Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No.1272/2008.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
The result of the testing of MPG, propoxylated according to the LLNA procedure does not warrant classification in the EU.
Based on the skin sensitization test results for Tetrapropylene Glycol classification is not warranted in accordance with Directive 67/548/EEC and EU Classification, Labelling, and Packaging of Substances and Mixtures (CLP) Regulation (EC)No. 1272/2008.
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