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EC number: 204-781-0 | CAS number: 126-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is not irritant to the rabbit skin.
The instillation of the test substance resulted in serious damage to the eyes. Effects may be simply due to a mechanical particle effect. However a chemical action of the substance can not be excluded.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
In a valid OECD Guideline study (OECD 404, adopted 1981) six rabbits were dermally exposed to 0.5 g neopentyl glycol (grinded and moistened with paraffin oil) for 4 h. Patches were removed and skin washed with water. Erythema and edema scores were read 1, 24, 48 und 72 h after patch removal and after 6, 8, 10, and 14 days. The max. mean score for erythema was 0.66 24 h after patch removal and for edema 0.33 24 and 48 h after removal (Huels 1985). In conclusion, only slight irritant effects to the skin of rabbits were induced; the test substance is not irritant to the skin.
Similar results were reported by BASF AG (1982; comparable to OECD Guideline 404 with acceptable restrictions). No edema (score 0) and no erythema (score 0) was detected in any rabbit at any time point.
Eye irritation
In a study conducted according to OECD Guideline 405 (adopted 1981; Huels 1985) 3 male and 3 female rabbits received instillations of ca. 100 mg crystalline test substance into the left conjunctival sac, the right eye was untreated (control). Scoring according to the Guideline was performed 1, 24, 48, and 72 hours and 6, 8, 10, 13, 17 and 21 days after instillation. The first 72 h after instillation necrosis of nictitating and mucous membrane of the conjunctivae of all 6 rabbits were reported. At termination (day 21) irreversible damage in 2 out of 6 rabbits was obvious: opacity of the cornea (grading score 2, area involved score 2) accompanied by circumcorneal injection and iritis. Effects may be simply due to a mechanical particle effect. However a chemical action of the substance can not be excluded.
Conclusion: The instillation of the test substance resulted in serious damage to the eyes.
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Skin irritation
Data from two independent studies suggested that no classification and labelling according to EC Regulation No. 1272/2008 or
EU Directive 67/548/EEC is required.
Eye irritation
Induces serious damage to the eyes. The criteria for classification of EU Directive 67/548/EEC and Regulation (EC) No. 1272/2008 are met.
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