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EC number: 204-781-0 | CAS number: 126-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; post exposure period 7 days [but no later deaths expected]; no data about body weight)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dimethylpropane-1,3-diol
- EC Number:
- 204-781-0
- EC Name:
- 2,2-dimethylpropane-1,3-diol
- Cas Number:
- 126-30-7
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 2,2-dimethylpropane-1,3-diol
- Details on test material:
- 2,2-Dimethyl-1,3-propanediol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body weight at initiation: females 136-239 g, males 185-264 g
No further deails.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- 2 (200 mg/kg bw), 16 (1600 mg/kg bw), 30% (3200 & 6400 mg/kg bw) solution in water; vehicle: aqua dest; application volume 10, 10, 13.3, 21.3 ml/kg bw, respectively; no data about fasting prior to application.
- Doses:
- 200, 1600, 3200, 6400 mg/kg bw in males and females
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Details on study design:
- no further details
- Statistics:
- LD50 calculated (no details)
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Mortality:
- No mortality detected in any dose group.
- Clinical signs:
- other: Clinical signs occurred a few minutes after gavage in the high dose group: rats kept calm, slightly accelerated respiration; staggered gait, atony, apathy, and narkosis; no clinical signs during the following 7 days.
- Gross pathology:
- No treatment related effects.
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- In male and female rats the oral LD50 > 6400 mg/kg bw.
- Executive summary:
The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; post exposure period 7 days [but no later deaths expected]; no data about body weight).
Groups of 5 male and 5 female rats were gavaged with 2, 16, or 30% aqueous solutions at dose levels of 200, 1600, 3200, 6400 mg/kg bw. The post exposure observation period was 7 days. Clinical signs occurred a few minutes after gavage: rats kept calm, slightly accelerated respiration; staggered gait, atony, apathy, and narkosis; no clinical signs were observed during the following 7 days. No mortality was detected at any dose level. The test substance is practically non-toxic.
Conclusion: In male and female rats the oral LD50 > 6400 mg/kg bw.
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