Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-781-0 | CAS number: 126-30-7
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature; no details available
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The Neurotoxicity of Alcohols
- Author:
- Shoemaker WJ
- Year:
- 1 981
- Bibliographic source:
- Neurobehav Toxicol Teratol 3: 431-436
Materials and methods
- Principles of method if other than guideline:
- Neurotoxic effects in rats after i.p. injection
- GLP compliance:
- no
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- no details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- bw 250-350 g
no further details
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- single injection
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
no data
- No. of animals per sex per dose:
- no data
- Details on study design:
- no details
Examinations
- Observations and clinical examinations performed and frequency:
- no details
- Specific biochemical examinations:
- no data
- Neurobehavioural examinations performed and frequency:
- The intoxicating score is obtained by injecting different doses of the test substance i.p. into male Sprague-Dawley rats. The rating scale runs from 0-normal, 1-sedation, 2,3,4-increasing levels of ataxia, 5-loss of righting reflex, 6-coma, to 7-death.
The ED3 is defined as the dose to obtain a score of 3 on the intoxication scale. - Sacrifice and (histo)pathology:
- no data
Results and discussion
Results of examinations
- Details on results:
- No further details available. For comparison: ED3 for ethanol was 1500 mg/kg bw
Effect levels
- Dose descriptor:
- other: ED3
- Effect level:
- 2 000 other: mg/kg bw
- Sex:
- male
- Basis for effect level:
- other: The maximal response was obtained in 5 to 15 minutes; original value: 19.3 mmol/kg bw
- Remarks on result:
- other:
Applicant's summary and conclusion
- Conclusions:
- 2000 mg/kg bw i.p. resulted in a mid level of ataxia but no loss of righting reflex
- Executive summary:
Secondary literature, no details available.
In male Sprague-Dawley rats single i.p. injection of 2000 mg/kg bw resulted in a mid level of ataxia but no loss of righting reflex.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
