Registration Dossier
Registration Dossier
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EC number: 202-411-2 | CAS number: 95-33-0
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Correlation of chemical structure with reproductive aand developmental toxicity as it relates to the use of the threshold of toxicological concern
- Author:
- Laufersweiler MC, Gadagbui B, Baskerville-Abraham IM, maier A, Willis A, Scialli AR, Carr GJ, Felter SP, Blackburn K, Daston G
- Year:
- 2 012
- Bibliographic source:
- Reg Toxicol Pharmacol 62 (2012) 160-182
Materials and methods
- Principles of method if other than guideline:
- An examination was performed if the threshold of toxicological concern (TCC) derrived from repeated dose toxicity studies is also protective for reproductive/developmental toxicity as well. In this examination Cyclohexylbenzothiazol-2-sulphenamide (CAS 95-33-0) was included.
- Type of method:
- other: Evaluation of literature data.
- Endpoint addressed:
- toxicity to reproduction / fertility
- developmental toxicity / teratogenicity
Test material
- Reference substance name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- EC Number:
- 202-411-2
- EC Name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- Cas Number:
- 95-33-0
- Molecular formula:
- C13H16N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
- Details on test material:
- No data
Constituent 1
Results and discussion
- Details on results:
- The present analysis indicates that, for each Cramer Class, the reproductive and developmental endpoints would be protected at the corresponding general TTC tiers derived by Munro et al., Food Chem. Toxicol. 34, 829-867 (1996).
Applicant's summary and conclusion
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