Registration Dossier
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EC number: 202-411-2 | CAS number: 95-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The chronic toxicity of CBS to aquatic invertebrates (Dapnia magna) was tested according to OECD TG 211 "Daphnia magna Reproduction test". After 21 days of exposure an EC50 of 0.12 mg/L and a NOEC of 0.058 mg/L were obtained (National Institute of Technology and Evaluation, 1996).
No data are available regarding the hydrolysis products from CBS, such as BT and BTon, but some are available from other relevant metabolites of CBS such as MBT. The chronic toxicity of MBT to Daphnia magna was investigated in a flow-through system (CMA, 1989). The NOEC-21d and EC50 -21d was reported as 0.24 mg/l (measured) and >0.47 mg/l (measured), respectively.
Regarding the data summarized here, the long-term toxicities of the described metabolites of CBS to aquatic invertebrate are lower than the one of CBS itself.
Key value for chemical safety assessment
Additional information
A hydrolysis half-life time of CBS of 12.5 h and a complete hydrolysis of CBS in 24.9 h were observed in deionized water buffered at pH 7.0 and at 25°C (Monsanto, 1984). MITI online did not provide detailed information, whether the effect concentrations were nominal concentrations or from analytical monitoring. The observed effect is most probably a combined effect from both CBS and its hydrolysis products. The reported effective concentrations are lower than water solubility of CBS (i.e. 0.32 mg/l).
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