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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: non-GLP study from peer-reviewed secondary source

Data source

Reference
Reference Type:
secondary source
Title:
European Union Risk Assessment Report: 1-vinyl-2-pyrrolidone, CAS: 88-12-0, 2nd Priority List, Volume 39
Author:
European Commission
Year:
2003
Bibliographic source:
available at: http://echa.europa.eu/documents/10162/1ebf6d5f-e907-4ca2-a3b4-909fd5f359d1

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
Remarks:
limited details available
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Intact skin. No other data.
Duration of exposure:
no data
Doses:
200, 375, 800, 1000, or 2000 mg/kg of test substance
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
560 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
LD100
Effect level:
1 000 mg/kg bw
Based on:
test mat.
Mortality:
At ≥375 mg/kg-bw, mortality was seen within 5 days of dosing; at ≥1000 mg/kg-bw, mortality was 100%; no mortality occurred at the low dose of 200 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU