Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted method of estimation for risk assessment

Data source

Reference
Reference Type:
other: Estimate
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Estimated using U.S. EPA DERMWIN v1.43a (September 2008)
Principles of method if other than guideline:
The Dermal Permeability Coefficient Program (DERMWIN) estimates the dermal permeability coefficient (Kp) and the dermally absorbed dose per event (DAevent) of organic compounds.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES : O=C(N(C=C)CC1)C1
CHEM : 2-Pyrrolidinone, 1-ethenyl-
MOL FOR: C6 H9 N1 O1
MOL WT : 111.14
Log Kow: 0.4 (user entered)
Radiolabelling:
no

Test animals

Species:
other: Estimate
Strain:
other: Estimate

Administration / exposure

Details on study design:
Log Kow (user-entered): 0.4 (used in Kp calculations)

GENERAL Equation: log Kp = -2.72 + 0.71 log Kow - 0.0061 MW

Results and discussion

Any other information on results incl. tables

GENERAL Equation:  Kp (predicted): 7.69e-004 cm/hr

 

Dermally Absorbed Dose per Event:

  Water Conc (mg/cm3): 49 (estimated by program)

  Event Duration (hr): 1

  DA(event): 0.038 mg/cm2-event (using Fick's first law)

  DA(event): 0.067 mg/cm2-event (using eqn 5.20 & 5.21)

                  (tau = 0.42 hr, t* = 1 hr)

Applicant's summary and conclusion