Registration Dossier
Registration Dossier
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EC number: 209-062-5 | CAS number: 554-13-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Lithium carbonate teratogenic effects in chick cardiomyocyte micromass system and mouse embryonic stem cell derived cardiomyocyte - Possible protective role of myo-inositol
- Author:
- W.M. Shaikh Qureshi, M.L Latif, T.L Parker, M.K. Pratten
- Year:
- 2 014
- Bibliographic source:
- Reproductive Toxicology 46 (2014) 106-114
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Lithium carbonate
- EC Number:
- 209-062-5
- EC Name:
- Lithium carbonate
- Cas Number:
- 554-13-2
- Molecular formula:
- CH2O3.2Li
- IUPAC Name:
- dilithium carbonate
- Test material form:
- solid
Constituent 1
Results and discussion
Any other information on results incl. tables
In chick embryonic cardiomyocyte micromas system (MM) the lithium carbonate did not alter the toxicity estimation endpoints (contractile activity, cellular toxicity, cellular protein content, ROS), whereas in embryonic stem cell derived Cardiomyocyte (ESDC) system the cardiomyocytes contractile activity stopped at 1500 p.M and above with significant increase in total cellular protein contents.
Applicant's summary and conclusion
- Executive summary:
Shaikh et al. (2014) evaluated the toxic effect of lithium carbonate in chick embryonic cardiomyocyte mircomass system (MM) and embryonic stem cell derived cardiomyocyte (ESDC), with possible protective role of myo-inositol. In chick embryonic cardiomyocyte micromas system (MM) the lithium carbonate did not alter the toxicity estimation endpoints (contractile activity, cellular toxicity, cellular protein content, ROS), whereas in embryonic stem cell derived Cardiomyocyte (ESDC) system the cardiomyocytes contractile activity stopped at 1500 µM and above with significant increase in total cellular protein contents.
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