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Toxicological information


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Administrative data

Description of key information

2 year carcinogenicity studies in rats and mice were carried out according to EU method B.33. Studies showed that the monosodium salt of cyanuric acid was non-oncogenic by the oral route.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
154 mg/kg bw/day

Justification for classification or non-classification

In both studies, under the experimental conditions, there is no evidence of carcinogenic potential of the test material

Additional information

Two carcinogenicity drinking water studies with monosodium cyanurate monohydrate (77.4 - 77.5% CYA) were performed, one in the rat and the other in the mouse. In both studies there is no evidence of carcinogenic potential of the test material. The lowest NOEL derived was that in male rats 154 mg/kg bw/day (Blair M 1985) due to test substance related urinary tract lesions which occurred in the first half of the study. At the highest dose, the test substance precipitated in the urinary bladder. No treatment related effects were observed in the study performed with mice.