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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Crude cyanuric acid
- Physical state: Solid balls
- Lot/batch No.: 3-30-81

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Isaac’s Farm, Litchfield, Illinois, USA
- Age at study initiation: Young adult
- Weight at study initiation: 2.34 - 3.13 kg
- Diet (e.g. ad libitum): Provided ad libitum
- Water (e.g. ad libitum): Provided ad libitum



Test system

Type of coverage:
occlusive
Preparation of test site:
abraded
Vehicle:
physiological saline
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 500 mg

Duration of treatment / exposure:
24 hour(s)
Observation period:
72 hours
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: Dorsal surface
- Type of wrap if used: Latex rubber


REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 72 hours


SCORING SYSTEM: Draize

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
8
Irritant / corrosive response data:
Slight irritation to one abraded site of one male animal was observed on the first day after exposure, while skins of the remaining five rabbits remained normal throughout the study.

Any other information on results incl. tables

Table 1: Primary skin irritation to rabbits -Individual irritation scores

Animal number

Period (days)

Erythema

Edema

RFI

LBI

LFA

RBA

RFI

LBI

LFA

RBA

01M01

1

0

0

0

1

0

0

0

0

01M02

1

0

0

0

0

0

0

0

0

01M03

1

0

0

0

0

0

0

0

0

01F01

1

0

0

0

0

0

0

0

0

01F02

1

0

0

0

0

0

0

0

0

01F03

1

0

0

0

0

0

0

0

0

 

 

 

 

 

 

 

 

 

 

01M01

3

0

0

0

0

0

0

0

0

01M02

3

0

0

0

0

0

0

0

0

01M03

3

0

0

0

0

0

0

0

0

01F01

3

0

0

0

0

0

0

0

0

01F02

3

0

0

0

0

0

0

0

0

01F03

3

0

0

0

0

0

0

0

0

The primary irritation index for this group of animals is 0.0 on a scale of 0.0 to 8.0. Slight irritation to one abraded site of one male animal was observed on the first day after exposure, while skins of the remaining five animals appeared normal throughout the study. One male rabbit showed slight irritation to one of the abraded sites on one day but the remaining five animals appeared normal throughout the study.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Cyanuric acid is not irritating