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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyanuric acid
EC Number:
203-618-0
EC Name:
Cyanuric acid
Cas Number:
108-80-5
Molecular formula:
C3H3N3O3
IUPAC Name:
1,3,5-triazine-2,4,6-triol
Details on test material:
- Name of test material (as cited in study report): Crude cyanuric acid
- Lot/batch No.: Lot 3-30-81

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River Breeding Laboratories, Wilmington, MA. USA.
- Weight at study initiation: Males: 249 – 276 g; females: 181 – 202 g




Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: tap water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 397 mg/mL
- Amount of vehicle (if gavage): males ~0.7 ml; females ~0.5 ml

DOSAGE PREPARATION: The test material was ground into a powder and suspended in tap water at a concentration of 397 mg/ml.
Doses:
5000 mg/kg bw by gavage
No. of animals per sex per dose:
10 (5 male and 5 female)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations 3 times within the first 8 hours and twice daily thereafter. Body weights recorded on day 0, 7 and 14.
- Necropsy of survivors performed: yes(day 15)
Statistics:
None applied

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
No mortalities occured
Clinical signs:
other: Clinical abnormalities were observed in 2 animals, one of each sex, including lack of faecal material in both animals and sedation, ataxia and piloerection, porphyrin around the nose . With the exception of body weight loss these effects subsided by the 4
Gross pathology:
No effects noted

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Cyanuric acid is not classified