Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-254-7 | CAS number: 80-15-9
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity
- Remarks:
- subcutaneous
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 535 days
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: significant methodilogical deficiencies (i.e. only one dose, limited number of animals, pathological examinations only of the site of application, no adjustment for differences in survival, no statistics)
Data source
Reference
- Reference Type:
- publication
- Title:
- Carcinogenicity of epoxides, lactones, and peroxy compounds. IV Tumor response in epithelial and connective tissue in mice and rats
- Author:
- Van Duuren BL, Langseth L, Orris L, Teebor G, Nelson N, Kuschner M
- Year:
- 1 966
- Bibliographic source:
- J. Natl. Canc. Inst. Monogr. 37: 825-838
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ICR/Ha Swiss
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: tricaprylin
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 535 days
- Frequency of treatment:
- once weekly
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3.3 mg
Basis:
no data
- No. of animals per sex per dose:
- 30
- Control animals:
- other: concurrent vehicle and no treatment
Results and discussion
Results of examinations
- Relevance of carcinogenic effects / potential:
- Due to the methodical deficiencies of the study the results should be regarded as inconclusive.
Any other information on results incl. tables
1 fibrosarcoma was observed
median survival time was 472 days
Applicant's summary and conclusion
- Conclusions:
- In a s.c. carcinogenicity study with mice 1 fibrosarcoma was observed at the application site; due to the methodical deficiencies of the study the results should be regarded as inconclusive
- Executive summary:
Cumene hydroperoxide was tested for its carcinogenicity in mice; the substance was applied subcutaneously once weekly for 535 days to 30 mice; 1 fibrosarcima was observed at the application site; due to the methodololical deficiencies of the study the results should be regarded as inconclusive
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
