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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study well documented, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicity studies of certain organic peroxides and hydroperoxides
Author:
Floyd EP, Stokinger HE
Year:
1958
Bibliographic source:
Am Ind Hyg Assoc J 19: 205-212

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α-dimethylbenzyl hydroperoxide
EC Number:
201-254-7
EC Name:
α,α-dimethylbenzyl hydroperoxide
Cas Number:
80-15-9
Molecular formula:
C9H12O2
IUPAC Name:
1-methyl-1-phenylethyl hydroperoxide
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
7 weeks
Frequency of treatment:
three times weekly (monday, wednesday, friday)
Doses / concentrations
Remarks:
Doses / Concentrations:
19 mg/kg (one-fifth of LD50)
Basis:

No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

4/5 died; loss of weight; the pelage was coarse in most rats after first week of treatment

Applicant's summary and conclusion

Conclusions:
The repeated oral application of one-fith of LD50 of cumene hydroperoxide was toxic to rats
Executive summary:

Cumene hydroperoxide (one-fifth of LD50) was given orally to rats three times weekly for seven weeks; 4/5 animals died; the rats lost weight and the pelage was coarse.