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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1952

Materials and methods

Principles of method if other than guideline:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α-dimethylbenzyl hydroperoxide
EC Number:
201-254-7
EC Name:
α,α-dimethylbenzyl hydroperoxide
Cas Number:
80-15-9
Molecular formula:
C9H12O2
IUPAC Name:
1-methyl-1-phenylethyl hydroperoxide
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
other: undiluted or diluted in Dowanol 50B
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data

Results and discussion

Any other information on results incl. tables

Material

No. of

applications

Site

Rating - Response

100%

2

Ear

Moderate hyperemia, edema, necrosis

100%

1

Abdomen

Severe edema and necrosis, slight denaturation

10% sol.

10

Ear

Slight hyperemia, scaliness, crustation

10% sol.

4

Abdomen

Severe hyperemia and edema, moderate necrosis

1% sol.

10

Ear

Very slight hyperemia and scaliness

1% sol.

10

Abdomen

Moderate hyperemia and scaliness

0.1% sol.

10

Ear

Very slight hyperemia and scaliness

0.1% sol.

10

Abdomen

Sight scaliness

Applicant's summary and conclusion

Conclusions:
Cumene hydroperoxide undiluted and its strong solutions are severely irritating to the skin
Executive summary:

Cumene hydroperoxide was tested for skin irritation in rabbits; the undiluted substance and its strong solutions were severely irritating causing hyperemia, edema and necrosis