Registration Dossier
Registration Dossier
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EC number: 200-871-9 | CAS number: 75-45-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Principles of method if other than guideline:
- probably equivalent or according to OECD 403
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chlorodifluoromethane
- EC Number:
- 200-871-9
- EC Name:
- Chlorodifluoromethane
- Cas Number:
- 75-45-6
- Molecular formula:
- CHClF2
- IUPAC Name:
- chlorodifluoromethane
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- sex distribution and strain not reported
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- concentrations of 32000, 64000, 128000 and 250000 ppm
- No. of animals per sex per dose:
- 4 groups of 6 rats (sex distribution and strain not reported) were exposed
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 250 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- One mortality was observed at the 250000 ppm concentration.
No LC50 was reported. - Clinical signs:
- other: Clinical observations included poor coordination and prostration.
- Body weight:
- no data
- Gross pathology:
- Gross necropsy revealed blood in intestines and scattered lung consolidation.
- Other findings:
- no data
Any other information on results incl. tables
not available
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: expert judgement
- Conclusions:
- not available
- Executive summary:
- In an acute inhalation toxicity test 4 groups of 6 rats (sex distribution and strain not reported) were exposed for 4 hours to chlorodifluoromethane vapors at concentrations of 32000, 64000, 128000 and 250000 ppm. Only one mortality was observed at the 250000 ppm concentration.
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