Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Principles of method if other than guideline:
probably equivalent or according to OECD 403
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorodifluoromethane
EC Number:
200-871-9
EC Name:
Chlorodifluoromethane
Cas Number:
75-45-6
Molecular formula:
CHClF2
IUPAC Name:
chloro(difluoro)methane
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
sex distribution and strain not reported

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
concentrations of 32000, 64000, 128000 and 250000 ppm
No. of animals per sex per dose:
4 groups of 6 rats (sex distribution and strain not reported) were exposed
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LC100
Effect level:
250 000 ppm
Based on:
test mat.
Exp. duration:
4 h
Mortality:
One mortality was observed at the 250000 ppm concentration.
No LC50 was reported.
Clinical signs:
other: Clinical observations included poor coordination and prostration.
Body weight:
no data
Gross pathology:
Gross necropsy revealed blood in intestines and scattered lung consolidation.
Other findings:
no data

Any other information on results incl. tables

not available

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: other: expert judgement
Conclusions:
not available
Executive summary:
In an acute inhalation toxicity test 4 groups of 6 rats (sex distribution and strain not reported) were exposed for 4 hours to chlorodifluoromethane vapors at concentrations of 32000, 64000, 128000 and 250000 ppm. Only one mortality was observed at the 250000 ppm concentration.