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Registration Dossier
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EC number: 283-392-8 | CAS number: 84605-29-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study; use of non-standard vehicle for dosing
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
- EC Number:
- 283-392-8
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
- Cas Number:
- 84605-29-8
- Molecular formula:
- Not applicable
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 6-7 weeks
- Weight at study initiation: 160 to 200 g (male), 140-180 g (female)
- Fasting period before study:
- Housing: Individually in stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: 10% aqueous dispersion of gum Arabic
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal zone
- % coverage:
- Type of wrap if used: aluminum foil fastened by a bandaid
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with warm water
- Time after start of exposure: 25 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4 ml/kg
- Concentration (if solution): 50.04 g/100mL
- Constant volume or concentration used: yes
- For solids, paste formed:
VEHICLE
- Amount(s) applied (volume or weight with unit): 4 ml/kg
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of exposure:
- 25 hours
- Doses:
- 0 and 2002 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 7, and 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 002 mg/kg bw
- Mortality:
- 0 mg/kg: 0/10 dead
2002 mg/kg: 0/10 dead - Clinical signs:
- other: Prostration in one animal. No other behavioral anomalies. Desquamation of the skin noted on test day 11.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Based on the low level of toxicity and no mortality observed at 2002 mg/kg, material is not classified for acute dermal toxicity.
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