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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
other: Expert Statement
Adequacy of study:
supporting study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Statement is based on valid study data.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Principles of method if other than guideline:
The physicochemical properties of the test substance, and extensive ecotoxicity studies provide strong support in determining the bioaccumulation potential for this substance, and therefore may substitute for the experimentation of in vivo effects.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Results and discussion

Any other information on results incl. tables

Bioaccumulation (B) (see copy of ECHA screening criteria in Appendix A)

 

3.3.1   Screening data

 

Based on read across from a structurally similar ZDDP compound that was tested for bioconcentration in fish, this substance is expected to have a low potential for bioaccumulation (Japanese MITI database, Gazette reference number 2-22945, “Zinc dialkyl dithiophosphate”;www.safe.nite.go.jp). The bioconcentration test was conducted in carp for 6 weeks at two concentrations (0.1 mg/L and 1.0 mg/L) and the resulting BCF values were all less than 100 -- MITI classified ZDDP as “non or not highly bioaccumulative”.

 

No empirical test data for structurally similar substances were found using the OECD Toolbox and ToxMatch program. 

 

Based on read-across to soluble complexes of zinc, measured BCF data reported in the U.S. EPA’s Ecotox Database shows that BCF values in various species including fish are much less than the screening criteria of the Guidance of 2,000.

 

Measured data on structurally similar substances as identified by the CAESAR database shows BCF values less than 1,000 (CAESAR dataset molecules ID 405 and 303).

 

Read-across evidence on bioaccumulation potential for this UVCB substance can also be taken from Environment Canada’s screening assessment (January 2010) for the ZDDP EC#2186799 (CAS#2215-35-2), which determined that the “substance has a low potential to accumulate in the lipid tissues of organisms”. Based on Environment Canada’s analysis, modeled data in fish resulted in fish BCF values less than 100 using the OASIS Forecast 2005 and BCFWIN models. 

Based on their analysis of available evidence, Environment Canada concluded that the ZDDP studied “is expected to have low bioaccumulation potential due to its physical and chemical properties”, in agreement with conclusions of the U.S. EPA which considers this group of substances to have low bioaccumulation potential (US EPA 2008).

 

QSAR predicted data from structurally similar (>90% Tanimoto index) substances found in the OECD toolbox had BCF values significantly less than the screening criterion. The CAS number provided by the OECD Toolbox for this structurally similar substance was #7405-05-2.

 

The OECD Toolbox also predicts No binding to protein for this substance. Protein binding has been shown to contribute to the bioconcentration potential of substances in aquatic species (Fairbrother et al. 2007; Cowan-Ellsberry et al. 2008; Franke 1996; Legierse et al. 1998; Tremolada et al. 2009; Veltman et al. 2006). Metal substances may form complexes with proteins for distribution, sequestration, and excretion depending on the substance’s relative bioaccessibility and bioavailability.

 

3.3.2   Measured data

Based on the measured log Kow (per OECD 107 guidelines) value of 0.56, this substance is not bioaccumulative based on the ECHA octanol water partitioning coefficient criterion. The mechanisms for uptake and depuration of compounds containing metals are complex and variable.

.

 

3.3.3   Other supporting information

 

3.3.4   Summary and discussion of bioaccumulation

Based on the weight of evidence from read across to structurally similar ZDDP substances with BCF data in fish (from Japanese MITI data, US EPA database, CAESAR database), measured Low Kow data, and QSAR predictions, this substance is expected to have low bioaccumulation potential. This substance does not meet the criteria of concern for bioaccumulation.

 

 

Table. Criteria for Bioaccumulation

Parameter

ECHA Criterion*

Results for Substance

Screening Assignment based on Data for Substance

Octanol-water partitioning coefficient

Log Kow ­<4.5

Log Kow 0.56

Not B

Structural similarity or class of chemicals

Similarity to class of chemicals known to accumulate in living organisms ?

Material is not structurally similar to any known materials that fulfill the screening criteria

Not B

Not vB

BCF in Fish

<2,000 L/kg

CAESAR read across from structurally similar substances with experimental BCF values

Not B

Not vB

BCF in Fish

<2,000 L/kg

Measured BCF less than 100 in carp for structurally similar ZDDP substance as reported in Japanese MITI database

Not B

Not vB

BCF in Fish

<2,000 L/kg

EPA Ecotox Database for Zinc compounds

Not B

Not vB

QSAR

BCF in Fish

Environment’s BCF predictions using OASIS and BCFWIN models for a surrogate ZDDP

Not B

Not vB

* Based on criterion described in ECHA 2008, “Guidance on information requirements and chemical safety assessment. Chapter R.11: PBT Assessment”

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
Based on the weight of evidence from read across to structurally similar ZDDP substances with BCF data in fish (from Japanese MITI data, US EPA database, CAESAR database), measured Log Kow data, and QSAR predictions, this substance is expected to have low bioaccumulation potential. This substance does not meet the criteria of concern for bioaccumulation.