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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

NOEC 21d Daphnia: 6.59 mg/l

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
6.59 mg/L

Additional information

A Daphnia magna reproductive study is available on CAS 16470-24-9 with NOEC reported as geometric mean because the difference between nominal and measured values is often greater than ± 20 %. The test was performed on a similar substance within the category of Stilbene Fluorescent Whitening Agents, the analogous dihydroxyethyl derivative tetrasulphonated sodium salt.

This substance can be considered the best representative within the category, since it has the same sulphonation degree than CAS 67786-25-8, a very high structural similarity (Tanimoto distance > 0.9) and a very high water solubility (650 g/l Vs 1000 g/l of CAS 67786-25-8) (details in the category Justification Report, attached to the Section 13 of the dossier).

The structural difference is on the hydroxyl substitution that is primary in CAS 16470-24-9 and secondary in CAS 67786-25-8. This leads at a less possible reactivity also from a potential toxicological point of view. The acute aquatic toxicity studies do not reveal any concern at any trophic level for both substances. It can be therefore assumed that the result for CAS 16470-24-9 is valid for the substance under registration.